26 Holly Creek Drive
Anderson, South Carolina 29621

About Guffee Dental

Whether you are new to our practice or a long-time patient, we hope you’ll find our website to be a valuable resource. Our dentists are committed to providing the highest quality dental care while still providing patients with the time and attention every individual deserves.

Our Staff

Learn a little more about our friendly staff. They look forward to getting to know you too!

Read The Bios

The Guffee Dental Difference

Before & After

From small improvements such as porcelain veneers to complete dental makeovers, Dr. Byron Guffee is experienced with all facets of dentistry and can bring you the smile and dentition that you desire.

See The Difference

Visit Our New Location!

Guffee Dental Logo

Chairside Economical Restorations of Esthetic Ceramic or CEREC® for short is a new state-of-the-art method of reconstructing tooth restorations. CEREC® uses computer-assisted design (CAD) and computer-aided manufacturing (CAM) to offer single-day restorations for patients. This new technology has revolutionized ceramic restorations such as crowns and veneers for patients so that there is no longer a wait between preparing the restoration and finally receiving the finished product. With CEREC®, the technology is used while you are sitting in the dental chair, which is both economical for you and your dentist.

Read More About Cerec


As always, Terry did a wonderful job of cleaning my teeth! She and all the staff are always very friendly. I highly recommend Dr. Guffee and Dr. Weed, the best dental team in town!

Julie B. - Patient

Everyone is extremely friendly and they make you feel at ease. The office is beautiful and super clean! Very thankful for a business that is willing to play Christian music for their patients!!

Renee Murdock - Patient

Great service. Everyone is super friendly. They are always able to get me in quickly. I would not go anywhere else!

Jaimee Sargent - Patient

We absolutely LOVE Guffee Dental! Not only is the dental care top notch but the staff are kind and patient and the christian atmosphere is very relaxing and welcoming.

Kathy West - Patient

Dr. Guffee is the best dentist we have ever used. If you are looking for a new dental practice please call Duffee Dental Associates.

Sharon Splawn - Patient

Guffee dental is awesome. The kindest staff and the atmosphere is very relaxing. I have always dreaded going to the dentIst but Dr Guffee and his staff make it a pleasant experience.

Kelly Copelan - Patient